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Anti-BANF1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BANF1 Antibody

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Overview

Name:	Anti-BANF1 Antibody See all BANF1 primary antibodies
Description:	Rabbit polyclonal antibody to BANF1
Applications:	E, WB, IF
Reactivity:	Human, Mouse
Immunogen:	Raised against a 15 amino acid peptide from near the carboxy terminus of human BANF1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-s which may promote DNA cross-bridging.
Sequence Similarities:	Belongs to the BAF family.
Post-Translational Modification:	Ser-4 is the major site of phosphorylation as compared to Thr-2 and Thr-3. Phosphorylation on Thr-2; Thr-3 and Ser-4 disrupts its ability to bind DNA and reduces its ability to bind LEM domain-containing proteins. Non phosphorylated BAF seems to enhance binding between EMD and LMNA. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with ANKLE2/LEM4 during mitotic exit, leading to mitotic nuclear envelope reassembly.
Cellular Location:	Nucleus. Cytoplasm. Chromosome. Nucleus envelope. Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus.
Database Links:	Entrez Gene: 8815 Human Entrez Gene: 23825 Mouse Omim: 603811 Human SwissProt: O75531 Human SwissProt: O54962 Mouse Unigene: 433759 Human Unigene: 358649 Mouse
Synonyms:	BAF Antibody BAF_HUMAN Antibody BANF 1 Antibody BANF1 Antibody Barrier to autointegration factor Antibody Barrier to autointegration factor 1 Antibody Barrier-to-autointegration factor Antibody BCRG 1 Antibody BCRG1 Antibody BCRP 1 Antibody BCRP1 Antibody Breakpoint cluster region protein 1 Antibody D14S1460 Antibody MGC111161 Antibody NGPS Antibody
Information:	Target information shown above is from the UniProt Consortium.