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Anti-BAG3 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-BAG3 Antibody

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Overview

Name:	Anti-BAG3 Antibody See all BAG3 primary antibodies
Description:	Goat polyclonal antibody to BAG3.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human BAG3 (internal region).
Sequence:	C-KNAGNAEDPHTE
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Involvement in Disease:	Myopathy, myofibrillar, 6: A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disc and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. Cardiomyopathy, dilated 1HH: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cellular Location:	Nucleus. Cytoplasm. Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:26159920).
Database Links:	Entrez Gene: 9531?Human Omim: 603883?Human SwissProt: O95817?Human Unigene: 523309?Human
Synonyms:	BAG 3 Antibody BAG family molecular chaperone regulator 3 Antibody BAG-3 Antibody Bag3 Antibody BAG3_HUMAN Antibody Bcl 2 binding protein Antibody Bcl-2-associated athanogene 3 Antibody Bcl-2-binding protein Bis Antibody BCL2 associated athanogene 3 Antibody BCL2 binding athanogene 3 Antibody BIS Antibody CAIR 1 Antibody Docking protein CAIR 1 Antibody Docking protein CAIR-1 Antibody MFM6 Antibody
Information:	Target information shown above is from the UniProt Consortium.