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Anti-BAG3 Antibody

品牌：Antibodies

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规格：50µl

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Anti-BAG3 Antibody

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Overview

Name:	Anti-BAG3 Antibody See all BAG3 primary antibodies
Description:	Rabbit polyclonal antibody to BAG3
Specificity:	The antibody detects endogenous levels of total BAG3 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human BAG3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Involvement in Disease:	Myopathy, myofibrillar, 6: A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disc and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. Cardiomyopathy, dilated 1HH: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cellular Location:	Nucleus. Cytoplasm. Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:26159920).
Database Links:	Entrez Gene: 9531?Human Omim: 603883?Human SwissProt: O95817?Human Unigene: 523309?Human
Synonyms:	BAG 3 Antibody BAG family molecular chaperone regulator 3 Antibody BAG-3 Antibody Bag3 Antibody BAG3_HUMAN Antibody Bcl 2 binding protein Antibody Bcl-2-associated athanogene 3 Antibody Bcl-2-binding protein Bis Antibody BCL2 associated athanogene 3 Antibody BCL2 binding athanogene 3 Antibody BIS Antibody CAIR 1 Antibody Docking protein CAIR 1 Antibody Docking protein CAIR-1 Antibody MFM6 Antibody
Information:	Target information shown above is from the UniProt Consortium.