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Anti-BAG-1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BAG-1 Antibody

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Overview

Name:	Anti-BAG-1 Antibody See all BAG-1 primary antibodies
Description:	Rabbit polyclonal antibody to BAG-1
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 14 amino acid peptide from near the amino terminus of human BAG-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
Post-Translational Modification:	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 573?Human Entrez Gene: 12017?Mouse Entrez Gene: 297994?Rat Omim: 601497?Human SwissProt: Q99933?Human SwissProt: Q60739?Mouse SwissProt: B0K019?Rat Unigene: 377484?Human Unigene: 688?Mouse Unigene: 16320?Rat
Synonyms:	Bag 1 Antibody BAG family molecular chaperone regulator 1 Antibody BAG-1 Antibody Bag1 Antibody BAG1_HUMAN Antibody BCL 2 associated athanogene Antibody BCL 2 Associated Athanogene 1 Antibody BCL 2 binding athanogene 1 Antibody Bcl-2-associated athanogene 1 Antibody BCL2 associated athanogene Antibody BCL2 associated athanogene 1 Antibody Glucocorticoid receptor-associated protein RAP46 Antibody HAP1 Antibody Haptoglobin Antibody RAP 46 Antibody RAP46 Antibody
Information:	Target information shown above is from the UniProt Consortium.