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Anti-BAF250B Antibody

品牌：Antibodies

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规格：50µl

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Anti-BAF250B Antibody

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Overview

Name:	Anti-BAF250B Antibody See all BAF250B primary antibodies
Description:	Rabbit polyclonal antibody to BAF250B
Specificity:	The antibody detects endogenous levels of total BAF250B protein.
Applications:	WB, IF
Reactivity:	Human, Rat
Immunogen:	Synthesized peptide derived from interal of human BAF250B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their ***** state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.
Tissue Specificity:	Widely expressed with high levels in heart, skeletal muscle and kidney.
Involvement in Disease:	Coffin-Siris syndrome 1: A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 57492 Human Entrez Gene: 282546 Rat Omim: 614556 Human SwissProt: Q8NFD5 Human Unigene: 291587 Human Unigene: 22598 Rat Unigene: 228637 Rat
Synonyms:	6A3 5 Antibody ARID 1B Antibody ARID domain containing protein 1B Antibody ARID1B Antibody AT rich interactive domain 1B Antibody AT rich interactive domain 1B (SWI1 like) Antibody AT rich interactive domain containing protein 1B Antibody BAF 250b Antibody BAF-associated factor, 250-KD, B Antibody BAF250b Antibody BRG1 associated factor 250b Antibody BRG1 binding protein Antibody BRG1 binding protein ELD/OSA1 Antibody BRG1 binding protein hELD/OSA1 Antibody BRIGHT Antibody DAN 15 Antibody DAN15 Antibody Eld (eyelid)/Osa protein Antibody ELD/OSA1 Antibody hELD/OSA1 Antibody hOsa 2 Antibody hOsa2 Antibody KIAA1235 Antibody MRD12 Antibody OSA 2 Antibody Osa homolog 2 Antibody OSA2 Antibody OTTHUMP00000040115 Antibody p250R Antibody RP11 419L10.1 Antibody
Information:	Target information shown above is from the UniProt Consortium.