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Anti-B2M Antibody

品牌：Antibodies

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规格：100µg

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Anti-B2M Antibody

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Overview

Name:	Anti-B2M Antibody See all B2M primary antibodies
Description:	Mouse monoclonal (KT134) antibody to B2M
Applications:	ELISA, WB, sELISA
Reactivity:	Human
Immunogen:	Purified native human B2M.
Host:	Mouse
Clonality:	Monoclonal
Clone:	KT134
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	IgG is purified through a Protein A column.
Concentration:	1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Involvement in Disease:	Immunodeficiency 43: A disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease. Amyloidosis 8: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
Sequence Similarities:	Belongs to the beta-2-microglobulin family.
Post-Translational Modification:	Glycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular Location:	Secreted. Cell surface. Detected in serum and urine (PubMed:1336137, PubMed:7554280).
Database Links:	Entrez Gene: 567 Human Omim: 109700 Human SwissProt: P61769 Human Unigene: 534255 Human Unigene: 702947 Human
Synonyms:	B2M Antibody B2MG_HUMAN Antibody Beta 2 microglobin Antibody beta 2 Microglobulin Antibody Beta 2 microglobulin precursor Antibody Beta chain of mhc class 1 proteins Antibody Beta chain of MHC class I molecules Antibody Beta-2-microglobulin form pI 5.3 Antibody CDABP0092 Antibody Hdcma22p Antibody IMD43 Antibody
Information:	Target information shown above is from the UniProt Consortium.