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Anti-AXIN2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-AXIN2 Antibody

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Name:	Anti-AXIN2 Antibody See all AXIN2 primary antibodies
Description:	Rabbit polyclonal antibody to AXIN2
Specificity:	The antibody detects endogenous level of total AXIN2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human AXIN2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Function:	Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).
Tissue Specificity:	Expressed in brain and lymphoblast.
Involvement in Disease:	Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Oligodontia-colorectal cancer syndrome: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
Post-Translational Modification:	Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8313?Human Entrez Gene: 12006?Mouse Entrez Gene: 29134?Rat Omim: 604025?Human SwissProt: Q9Y2T1?Human SwissProt: O88566?Mouse SwissProt: O70240?Rat Unigene: 156527?Human Unigene: 71710?Mouse Unigene: 162212?Rat
Synonyms:	Axil Antibody Axin 2 Antibody Axin like protein Antibody Axin-2 Antibody Axin-like protein Antibody Axin2 Antibody AXIN2_HUMAN Antibody Axis inhibition protein 2 Antibody Conductin Antibody DKFZp781B0869 Antibody MGC10366 Antibody MGC126582 Antibody
Information:	Target information shown above is from the UniProt Consortium.