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Anti-AXIN1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-AXIN1 Antibody

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Overview

Name:	Anti-AXIN1 Antibody See all AXIN1 primary antibodies
Description:	Rabbit polyclonal antibody to AXIN1
Specificity:	The antibody detects endogenous levels of total AXIN1 protein.
Applications:	IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human AXIN1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Tissue Specificity:	Ubiquitously expressed.
Involvement in Disease:	Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Caudal duplication anomaly: A condition characterized by the occurrence of duplications of different organs in the caudal region.
Post-Translational Modification:	Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.
Cellular Location:	Cytoplasm. Nucleus. Membrane. Cell membrane. MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
Database Links:	Entrez Gene: 8312?Human Entrez Gene: 12005?Mouse Entrez Gene: 79257?Rat Omim: 603816?Human SwissProt: O15169?Human SwissProt: O35625?Mouse SwissProt: O70239?Rat Unigene: 592082?Human Unigene: 23684?Mouse Unigene: 31781?Rat
Synonyms:	AI316800 Antibody AXIN Antibody Axin 1 Antibody Axin-1 Antibody Axin1 Antibody AXIN1_HUMAN Antibody Axis inhibition protein 1 Antibody Axis Inhibitor 1 Antibody Fu Antibody fused Antibody Fused, mouse, homolog of Antibody hAxin Antibody Kb Antibody Ki Antibody kinky Antibody knobbly Antibody MGC132911 Antibody MGC52315 Antibody PPP1R49 Antibody Protein Fused Antibody Protein phosphatase 1 regulatory subunit 49 Antibody
Information:	Target information shown above is from the UniProt Consortium.