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Anti-AURKC Antibody

品牌：Antibodies

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规格：100µg

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Anti-AURKC Antibody

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Overview

Name:	Anti-AURKC Antibody See all Aurora C primary antibodies
Description:	Goat polyclonal antibody to AURKC.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human AURKC (N terminal).
Sequence:	PRAVVQLGKAQP-C
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Tissue Specificity:	Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Involvement in Disease:	Spermatogenic failure 5: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Cellular Location:	Nucleus. Chromosome. Chromosome > Centromere. Cytoplasm > Cytoskeleton > Spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Database Links:	Entrez Gene: 6795 Human Omim: 603495 Human SwissProt: Q9UQB9 Human Unigene: 98338 Human
Synonyms:	AURKC Antibody AIE 2 Antibody Aie1 Antibody AIE2 Antibody AIK 3 Antibody AIK3 Antibody ARK 3 Antibody ARK-3 Antibody ARK3 Antibody Aur C Antibody AurC Antibody Aurkc Antibody AURKC_HUMAN Antibody aurora 3 Antibody Aurora C Antibody Aurora kinase C Antibody aurora related kinase 3 Antibody Aurora-related kinase 3 Antibody Aurora/Ipl1 related kinase 3 Antibody Aurora/Ipl1-related kinase 3 Antibody Aurora/Ipl1/Eg2 protein 2 Antibody EC 2.7.11.1 Antibody IPL-1/STK13/Aurora C Antibody Serine threonine protein kinase 13 Antibody serine/threonine kinase 13 (aurora/IPL1 like) Antibody serine/threonine protein kinase aurora C Antibody Serine/threonine-protein kinase 13 Antibody Serine/threonine-protein kinase aurora-C Antibody SPGF5 Antibody STK13 Antibody
Information:	Target information shown above is from the UniProt Consortium.