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Anti-ATP2A1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATP2A1 Antibody

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Overview

Name:	Anti-ATP2A1 Antibody See all ATP2A1 primary antibodies
Description:	Rabbit polyclonal antibody to ATP2A1
Specificity:	The antibody detects endogenous levels of total ATP2A1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Tissue Specificity:	Skeletal muscle, fast twitch muscle (type II) fibers.
Involvement in Disease:	Brody myopathy: A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation.
Sequence Similarities:	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Cellular Location:	Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane.
Database Links:	Entrez Gene: 487?Human Entrez Gene: 11937?Mouse Omim: 108730?Human SwissProt: O14983?Human SwissProt: Q8R429?Mouse Unigene: 657344?Human Unigene: 35134?Mouse
Synonyms:	fast twitch skeletal muscle isoform Antibody AT2A1_HUMAN Antibody ATP2A Antibody ATP2A1 Antibody ATPase Ca++ transporting cardiac muscle fast twitch 1 Antibody ATPase Ca++ transporting fast twitch 1 Antibody ATPase, Ca(2+)-transporting fast twitch 1 Antibody Calcium pump 1 Antibody Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform Antibody Calcium-transporting ATPase sarcoplasmic reticulum type Antibody EC 3.6.3.8 Antibody Endoplasmic reticulum class 1/2 Ca(2+) ATPase Antibody Fast skeletal muscle SR calcium ATPase Antibody OTTHUMP00000162561 Antibody OTTHUMP00000162562 Antibody Sarcoendoplasmic reticulum calcium ATPase Antibody Sarcoplasmic reticulum Ca(2+)-ATPase 1 Antibody Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Antibody SERCA 1 Antibody SERCA1 Antibody SERCA1 ATPase Antibody SERCA1 truncated isoform, included Antibody SR Ca(2+) ATPase 1 Antibody SR Ca(2+)-ATPase 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.