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Anti-ATOH8 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATOH8 Antibody

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Overview

Name:	Anti-ATOH8 Antibody See all ATOH8 primary antibodies
Description:	Rabbit polyclonal antibody to ATOH8
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 15 amino acid peptide near the carboxy terminus of human ATOH8.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248).
Tissue Specificity:	Expressed by subsets of mature neurons (PubMed:11733035). Expressed in kidney (podocytes) (PubMed:16937370). Expression is restricted to the atria, lung mesenchyme, and vascular smooth muscle (PubMed:23836893).
Cellular Location:	Nucleus. Nucleus speckle. Cytoplasm.
Database Links:	Entrez Gene: 84913?Human Entrez Gene: 71093?Mouse Entrez Gene: 500200?Rat SwissProt: Q96SQ7?Human SwissProt: Q99NA2?Mouse Unigene: 135569?Human Unigene: 87449?Mouse
Synonyms:	4933425C05Rik Antibody ATOH8 Antibody ATOH8_HUMAN Antibody Atonal homolog 6 Antibody Atonal homolog 8 Antibody atonal homolog 8 (Drosophila) Antibody Basic helix loop helix transcription factor 6 Antibody bHLHa21 Antibody Class A basic helix-loop-helix protein 21 Antibody FLJ14708 Antibody FLJ38730 Antibody hATH6 Antibody Helix loop helix protein mATH-6 Antibody Helix-loop-helix protein hATH-6 Antibody Math6 Antibody Okadin Antibody Protein atonal homolog 8 Antibody RGD1561512 Antibody
Information:	Target information shown above is from the UniProt Consortium.