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Anti-ATG5 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATG5 Antibody

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Overview

Name:	Anti-ATG5 Antibody See all ATG5 primary antibodies
Description:	Chicken polyclonal antibody to ATG5
Specificity:	Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 16 amino acid peptide from near the amino terminus of human ATG5.
Host:	Chicken
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Sequence Similarities:	Belongs to the ATG5 family.
Post-Translational Modification:	Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Cellular Location:	Cytoplasm. Preautophagosomal structure membrane. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Database Links:	Entrez Gene: 9474?Human Entrez Gene: 11793?Mouse Entrez Gene: 365601?Rat Omim: 604261?Human SwissProt: Q9H1Y0?Human SwissProt: Q99J83?Mouse SwissProt: Q3MQ06?Rat Unigene: 486063?Human Unigene: 22264?Mouse Unigene: 98385?Rat
Synonyms:	APG 5 Antibody APG 5L Antibody APG5 Antibody APG5 autophagy 5 like Antibody APG5 like Antibody APG5-like Antibody APG5L Antibody APG5L/ATG5 Antibody Apoptosis specific protein Antibody Apoptosis-specific protein Antibody ASP Antibody ATG 5 Antibody Atg5 Antibody ATG5 autophagy related 5 homolog Antibody ATG5_HUMAN Antibody Autophagy protein 5 Antibody Autophagy related 5 Antibody hAPG5 Antibody Homolog of S Cerevisiae autophagy 5 Antibody OTTHUMP00000040507 Antibody
Information:	Target information shown above is from the UniProt Consortium.