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Anti-ATG4D Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATG4D Antibody

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Overview

Name:	Anti-ATG4D Antibody See all ATG4D primary antibodies
Description:	Rabbit polyclonal antibody to ATG4D
Specificity:	The antibody detects endogenous levels of total ATG4D protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Tissue Specificity:	Mainly expressed in skeletal muscle and, to a lower extent, in testis.
Sequence Similarities:	Belongs to the peptidase C54 family.
Post-Translational Modification:	Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondroal import of the protein.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 84971?Human Omim: 611340?Human SwissProt: Q86TL0?Human Unigene: 512799?Human
Synonyms:	9830134P12Rik Antibody APG4 autophagy 4 homolog D Antibody APG4 D Antibody APG4, S. cerevisiae, homolog of, D Antibody APG4D Antibody ATG4 autophagy related 4 homolog D (S. cerevisiae) Antibody ATG4D Antibody Atg4dl Antibody ATG4D_HUMAN Antibody AUT like 4 cysteine endopeptidase Antibody AUT-like 4 cysteine endopeptidase Antibody AUTL4 Antibody Autophagin 4 Antibody Autophagin-4 Antibody autophagy 4, S. cerevisiae, homolog of, D Antibody autophagy related 4D, cysteine peptidase Antibody Autophagy related cysteine endopeptidase 4 Antibody Autophagy related protein 4 homolog D Antibody Autophagy-related cysteine endopeptidase 4 Antibody Autophagy-related protein 4 homolog D Antibody Cysteine protease ATG4D Antibody Cysteine protease involved in autophagy Antibody MGC31226 Antibody
Information:	Target information shown above is from the UniProt Consortium.