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Anti-ATG13 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATG13 Antibody

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Overview

Name:	Anti-ATG13 Antibody See all ATG13 primary antibodies
Description:	Rabbit polyclonal antibody to ATG13
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 15 amino acid peptide near the carboxy terminus of human ATG13.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Sequence Similarities:	Belongs to the ATG13 family. Metazoan subfamily.
Post-Translational Modification:	Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-354 is required for efficient clearance of depolarized mitochondria.
Cellular Location:	Cytoplasm > Cytosol. Preautophagosomal structure. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Database Links:	Entrez Gene: 9776?Human Entrez Gene: 51897?Mouse Entrez Gene: 362164?Rat SwissProt: O75143?Human SwissProt: Q91YI1?Mouse Unigene: 127403?Human Unigene: 28492?Mouse Unigene: 98797?Rat
Synonyms:	ATG13 Antibody ATG13 autophagy related 13 homolog (S. cerevisiae) Antibody ATG13_HUMAN Antibody Autophagy related 13 Antibody Autophagy related protein 13 Antibody Autophagy-related protein 13 Antibody FLJ20698 Antibody KIAA0652 Antibody OTTHUMP00000233321 Antibody OTTHUMP00000233322 Antibody OTTHUMP00000233323 Antibody OTTHUMP00000233324 Antibody OTTHUMP00000233325 Antibody OTTHUMP00000233326 Antibody
Information:	Target information shown above is from the UniProt Consortium.