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Anti-ATG12 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATG12 Antibody

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Overview

Name:	Anti-ATG12 Antibody See all ATG12 primary antibodies
Description:	Rabbit polyclonal antibody to ATG12
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 15 amino acid peptide from near the center of human ATG12.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity).
Sequence Similarities:	Belongs to the ATG12 family.
Post-Translational Modification:	Acetylated by EP300.
Cellular Location:	Cytoplasm. Preautophagosomal structure membrane. TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Database Links:	Entrez Gene: 9140?Human Entrez Gene: 67526?Mouse Entrez Gene: 361321?Rat Omim: 609608?Human SwissProt: O94817?Human SwissProt: Q9CQY1?Mouse SwissProt: Q2TBJ5?Rat Unigene: 264482?Human Unigene: 9852?Mouse Unigene: 6224?Rat
Synonyms:	Apg12 Antibody APG12-like Antibody APG12L Antibody ATG12 Antibody ATG12 autophagy related 12 homolog Antibody ATG12 autophagy related 12 homolog (S. cerevisiae) Antibody ATG12_HUMAN Antibody Autophagy 12 Antibody Autophagy-related protein 12 Antibody FBR93 Antibody HAPG12 Antibody Ubiquitin-like protein ATG12 Antibody
Information:	Target information shown above is from the UniProt Consortium.