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Anti-ATF6 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ATF6 Antibody

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Overview

Name:	Anti-ATF6 Antibody See all ATF6 primary antibodies
Description:	Rabbit polyclonal antibody to ATF6
Applications:	E, WB, ICC
Reactivity:	Human, Mouse
Immunogen:	Raised against a 17 amino acid peptide from near the amino terminus of human ATF6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Achromatopsia 7: A form of achromatopsia, an ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus.
Sequence Similarities:	Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification:	During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
Cellular Location:	Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 22926 Human Entrez Gene: 226641 Mouse Omim: 605537 Human SwissProt: P18850 Human Unigene: 492740 Human
Synonyms:	Activating transcription factor 6 Antibody Activating transcription factor 6 alpha Antibody ATF 6 Antibody ATF6 Antibody ATF6 alpha Antibody ATF6-alpha Antibody ATF6A Antibody ATF6A_HUMAN Antibody cAMP dependent transcription factor ATF 6 alpha Antibody cAMP-dependent transcription factor ATF-6 alpha Antibody Cyclic AMP dependent transcription factor ATF 6 alpha Antibody DKFZp686P2194 Antibody ESTM49 Antibody FLJ21663 Antibody Processed cyclic AMP dependent transcription factor ATF 6 alpha Antibody Processed cyclic AMP-dependent transcription factor ATF-6 alpha Antibody
Information:	Target information shown above is from the UniProt Consortium.