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Anti-ATF1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-ATF1 Antibody

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Overview

Name:	Anti-ATF1 Antibody See all ATF1 primary antibodies
Description:	Rabbit polyclonal antibody to ATF1
Specificity:	The antibody detects endogenous levels of total ATF1 protein.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from internal of human ATF1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Involvement in Disease:	Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities:	Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification:	Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 466 Human Entrez Gene: 11908 Mouse Entrez Gene: 315305 Rat Omim: 123803 Human SwissProt: P18846 Human SwissProt: P81269 Mouse Unigene: 648565 Human Unigene: 473546 Mouse Unigene: 676 Mouse Unigene: 105304 Rat
Synonyms:	Activating transcription factor 1 Antibody ATF 1 Antibody ATF1 Antibody ATF1 EWS fusion gene Antibody ATF1 FUS fusion gene Antibody ATF1_HUMAN Antibody cAMP dependent transcription factor 1 Antibody cAMP-dependent transcription factor ATF-1 Antibody Cyclic AMP dependent transcription factor ATF 1 Antibody Cyclic AMP dependent transcription factor ATF1 Antibody Cyclic AMP-dependent transcription factor ATF-1 Antibody EWS AFT1 Antibody FUS ATF 1 Antibody FUS/ATF 1 Antibody Protein TREB36 Antibody RNA binding protein activating transcription factor 1 fusion protein Antibody TREB 36 Antibody TREB36 Antibody TREB36 protein Antibody
Information:	Target information shown above is from the UniProt Consortium.