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Anti-Ataxin-2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-Ataxin-2 Antibody

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Overview

Name:	Anti-Ataxin-2 Antibody See all Ataxin-2 primary antibodies
Description:	Rabbit polyclonal antibody to Ataxin-2
Specificity:	Ataxin-2 Polyclonal Antibody detects endogenous levels of Ataxin-2 protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human
Immunogen:	Synthesized peptide derived from the Internal region of human Ataxin-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Tissue Specificity:	Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Involvement in Disease:	Spinocerebellar ataxia 2: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is characterized by hyporeflexia, myoclonus and action tremor and dopamine-responsive parkinsonism. In some patients, SCA2 presents as pure familial parkinsonism without cerebellar signs. Amyotrophic lateral sclerosis 13: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Sequence Similarities:	Belongs to the ataxin-2 family.
Cellular Location:	Cytoplasm.