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Anti-ASTN2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ASTN2 Antibody

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Overview

Name:	Anti-ASTN2 Antibody See all ASTN2 primary antibodies
Description:	Rabbit polyclonal antibody to ASTN2
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Rabbit polyclonal ASTN2 (1) antibody was raised against a recombinated human ASTN2 protein 134-321aa (BC093835).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Target

Function:	Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (PubMed:20573900). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity).
Tissue Specificity:	Detected in cerebellum granule neurons; not detected in astroglia (at protein level). Detected primarily in cerebellum, and at lower levels in brain cortex, olfactory bulb, hindbrain and hippocampus dentate gyrus. Between 6 and 10 days after birth, when granule cell migration occurs in the cerebellum, detected in granule cell precursors in the external germinal layer, the molecular layer, the internal granule layer and in Purkinje neurons. Detected in postmitotic neurons in ***** cerebellum.
Sequence Similarities:	Belongs to the astrotactin family.
Cellular Location:	Membrane. Perikaryon. Cytoplasm > Cell cortex. Early endosome. Late endosome. Cytoplasmic vesicle > Clathrin-coated vesicle. Cytoplasmic vesicle. Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons.
Database Links:	Entrez Gene: 23245?Human Entrez Gene: 56079?Mouse Entrez Gene: 100361323?Rat Omim: 612856?Human SwissProt: O75129?Human SwissProt: Q80Z10?Mouse Unigene: 601562?Human Unigene: 445312?Mouse Unigene: 162821?Rat
Synonyms:	ASTN2 Antibody ASTN2_HUMAN Antibody Astrotactin 2 Antibody Astrotactin-2 Antibody bA264C15.1 Antibody bA67K19.1 Antibody KIAA0634 Antibody
Information:	Target information shown above is from the UniProt Consortium.