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Anti-PNPLA2 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-PNPLA2 Antibody

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Overview

Name:	Anti-PNPLA2 Antibody See all Adipose Triglyceride Lipase primary antibodies
Description:	Goat polyclonal antibody to PNPLA2.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human PNPLA2 (internal region).
Sequence:	C-PARPHGPEDKDQ
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Tissue Specificity:	Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).
Involvement in Disease:	Neutral lipid storage disease with myopathy: Neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
Post-Translational Modification:	Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation.
Cellular Location:	Lipid droplet. Cell membrane.
Database Links:	Entrez Gene: 57104 Human Omim: 609059 Human SwissProt: Q96AD5 Human Unigene: 654697 Human
Synonyms:	1110001C14Rik Antibody Adipose Triglyceride Lipase Antibody ATGL Antibody ATGL DESNUTRIN Antibody Calcium independent phospholipase A2 Antibody Calcium-independent phospholipase A2 Antibody Desnutrin Antibody EC 3.1.1.3 Antibody FP17548 Antibody IPLA2 zeta Antibody IPLA2-zeta Antibody Mutant patatin like phospholipase domain containing 2 Antibody Patatin like phospholipase domain containing 2 Antibody PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 Antibody Patatin-like phospholipase domain-containing protein 2 Antibody PEDF R Antibody PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA Antibody Pigment epithelium derived factor Antibody Pigment epithelium-derived factor Antibody plpl Antibody plpl2 Antibody PLPL2_HUMAN Antibody Pnpla2 Antibody Transport secretion protein 2 Antibody Transport secretion protein 2.2 Antibody Transport-secretion protein 2 Antibody Triglyceride hydrolase Antibody TTS 2.2 Antibody TTS2 Antibody TTS2.2 Antibody ZETA Antibody
Information:	Target information shown above is from the UniProt Consortium.