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Anti-PNPase Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-PNPase Antibody

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Overview

Name:	Anti-PNPase Antibody See all PNPase primary antibodies
Description:	Rabbit polyclonal antibody to PNPase
Specificity:	PNPase Polyclonal Antibody detects endogenous levels of PNPase protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from the C-terminal region of human PNPase.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
Involvement in Disease:	Combined oxidative phosphorylation deficiency 13: A mitochondrial disorder characterized by early onset severe encephalomyopathy, dystonia, choreoathetosis, bucofacial dyskinesias and combined mitochondrial respiratory chain deficiency. Nerve conductions velocities are decreased. Levels of plasma and cerebrospinal fluid lactate are increased. Deafness, autosomal recessive, 70: A form of non-syndromic deafness characterized by severe, bilateral hearing impairment with prelingual onset, resulting in inability to acquire normal speech.
Sequence Similarities:	Belongs to the polyribonucleotide nucleotidyltransferase family.
Cellular Location:	Cytoplasm. Mitochondrion. Mitochondrion intermembrane space.
Database Links:	Entrez Gene: 87178?Human Entrez Gene: 71701?Mouse GenBank: NP_149100.2?Human Omim: 610316?Human SwissProt: Q8TCS8?Human SwissProt: Q8K1R3?Mouse
Synonyms:	3' 5' RNA exonuclease Antibody COXPD13 Antibody DFNB70 Antibody old-35 Antibody OLD35 Antibody PNPASE Antibody PNPase 1 Antibody PNPT1 Antibody Polynucleotide phosphorylase like protein Antibody Polyribonucleotide nucleotidyltransferase 1, mitochondrial Antibody
Information:	Target information shown above is from the UniProt Consortium.