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Anti-PNN Antibody

品牌：Antibodies

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规格：50µl

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Anti-PNN Antibody

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Overview

Name:	Anti-PNN Antibody See all PNN primary antibodies
Description:	Rabbit polyclonal antibody to PNN
Specificity:	The antibody detects endogenous levels of total PNN protein.
Applications:	WB
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human PNN.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Tissue Specificity:	Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
Sequence Similarities:	Belongs to the pinin family.
Cellular Location:	Nucleus speckle. Cell junction > Desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Database Links:	Entrez Gene: 5411 Human Entrez Gene: 18949 Mouse Omim: 603154 Human SwissProt: Q9H307 Human SwissProt: O35691 Mouse Unigene: 409965 Human Unigene: 22347 Mouse
Synonyms:	140 kDa nuclear and cell adhesion-related phosphoprotein Antibody Desmosome-associated protein Antibody Domain-rich serine protein Antibody DRS Antibody DRS protein Antibody DRSP Antibody Melanoma metastasis clone A protein Antibody MEMA Antibody Nuclear protein SDK3 Antibody Pinin Antibody PININ_HUMAN Antibody PNN Antibody SR like protein Antibody SR-like protein Antibody
Information:	Target information shown above is from the UniProt Consortium.