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Anti-SMARCC2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SMARCC2 Antibody

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Overview

Name:	Anti-SMARCC2 Antibody See all SMARCC2 primary antibodies
Description:	Rabbit polyclonal antibody to SMARCC2.
Applications:	WB
Dilutions:	WB: 1:200 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse
Immunogen:	A synthetic peptide of human SMARCC2.
Protein Length:	1130
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their ***** state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Tissue Specificity:	Ubiquitously expressed.
Sequence Similarities:	Belongs to the SMARCC family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 6601?Human Entrez Gene: 68094?Mouse Omim: 601734?Human SwissProt: Q8TAQ2?Human SwissProt: Q6PDG5?Mouse Unigene: 236030?Human Unigene: 632717?Human Unigene: 417338?Mouse
Synonyms:	BAF 170 Antibody BAF170 Antibody BRG1 associated factor 170 Antibody BRG1-associated factor 170 Antibody Chromatin remodeling complex BAF170 subunit Antibody CRACC 2 Antibody CRACC2 Antibody Mammalian chromatin remodeling complex BRG1 associated factor 170 Antibody Rsc 8 Antibody Rsc8 Antibody SMARCC 2 Antibody Smarcc2 Antibody SMRC2 Antibody SMRC2_HUMAN Antibody SWI/SNF complex 170 kDa subunit Antibody SWI/SNF complex subunit SMARCC2 Antibody SWI/SNF related matrix associated actin dependent regulator of chromatin c2 Antibody SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 Antibody SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 Antibody SWI3 like protein Antibody
Information:	Target information shown above is from the UniProt Consortium.