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Anti-SMARCA5 Antibody

品牌：Antibodies

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规格：100µl

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Anti-SMARCA5 Antibody

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Overview

Name:	Anti-SMARCA5 Antibody See all SMARCA5 primary antibodies
Description:	Rabbit polyclonal antibody to SMARCA5
Specificity:	The antibody detects endogenous level of total SMARCA5 protein.
Applications:	WB, IHC, IF, IP, CHIP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SMARCA5.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Tissue Specificity:	Ubiquitously expressed.
Sequence Similarities:	Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 8467?Human Entrez Gene: 93762?Mouse Entrez Gene: 307766?Rat Omim: 603375?Human SwissProt: O60264?Human SwissProt: Q91ZW3?Mouse Unigene: 558422?Human Unigene: 246803?Mouse Unigene: 474173?Mouse Unigene: 128772?Rat
Synonyms:	4933427E24Rik Antibody D030040M08Rik Antibody D330027N15Rik Antibody EC 3.6.1.- Antibody hISWI Antibody hSNF2H Antibody ISWI Antibody MommeD4 Antibody SMARCA5 Antibody SMCA5_HUMAN Antibody SNF2H Antibody Sucrose nonfermenting like 5 Antibody Sucrose nonfermenting protein 2 homolog Antibody Sucrose nonfermenting, yeast, homolog of Antibody SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Antibody SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 Antibody SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Antibody WCRF135 Antibody
Information:	Target information shown above is from the UniProt Consortium.