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Anti-Smad6 (N372) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Smad6 (N372) Antibody

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Overview

Name:	Anti-Smad6 (N372) Antibody See all Smad6 primary antibodies
Description:	Rabbit polyclonal antibody to Smad6 (N372)
Specificity:	Smad6 (N372) pAb detects endogenous levels of Smad6 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 341-390 of Human Smad6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 53 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Tissue Specificity:	Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Involvement in Disease:	Aortic valve disease 2: A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.
Sequence Similarities:	Belongs to the dwarfin/SMAD family.
Post-Translational Modification:	Phosphorylated by BMP type 1 receptor kinase and by PRKX.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 4091?Human Entrez Gene: 17130?Mouse Entrez Gene: 367100?Rat Omim: 602931?Human SwissProt: O43541?Human SwissProt: O35182?Mouse Unigene: 153863?Human Unigene: 325757?Mouse
Synonyms:	hSMAD6 Antibody MAD homolog 6 Antibody MADH6 Antibody MADH7 Antibody Mothers against decapentaplegic homolog 6 Antibody Mothers against DPP homolog 6 Antibody SMAD 6 Antibody SMAD family member 6 Antibody SMAD mothers against DPP homolog 6 Antibody SMAD6 Antibody SMAD6_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.