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Anti-SMAD2 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-SMAD2 Antibody

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Overview

Name:	Anti-SMAD2 Antibody See all SMAD2 primary antibodies
Description:	Goat polyclonal antibody to SMAD2.
Applications:	ELISA, WB
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human SMAD2 (internal region).
Sequence:	SEIWGLSTPNTIDC
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Sequence Similarities:	Belongs to the dwarfin/SMAD family.
Post-Translational Modification:	In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Database Links:	Entrez Gene: 4087 Human Entrez Gene: 17126 Mouse Omim: 601366 Human SwissProt: Q15796 Human SwissProt: Q62432 Mouse Unigene: 12253 Human Unigene: 705764 Human Unigene: 152699 Mouse Unigene: 391091 Mouse
Synonyms:	Drosophila, homolog of, MADR2 Antibody hMAD-2 Antibody HsMAD2 Antibody JV18 Antibody JV18-1 Antibody JV181 Antibody MAD Antibody MAD homolog 2 Antibody MAD Related Protein 2 Antibody Mad-related protein 2 Antibody MADH2 Antibody MADR2 Antibody MGC22139 Antibody MGC34440 Antibody Mother against DPP homolog 2 Antibody Mothers against decapentaplegic homolog 2 Antibody Mothers against decapentaplegic, Drosophila, homolog of, 2 Antibody Mothers against DPP homolog 2 Antibody OTTHUMP00000163489 Antibody Sma and Mad related protein 2 Antibody Sma- and Mad-related protein 2 MAD Antibody SMAD 2 Antibody SMAD family member 2 Antibody SMAD, mothers against DPP homolog 2 Antibody Smad2 Antibody SMAD2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.