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Anti-Smad1 (P457) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Smad1 (P457) Antibody

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Overview

Name:	Anti-Smad1 (P457) Antibody See all Smad1 primary antibodies
Description:	Rabbit polyclonal antibody to Smad1 (P457)
Specificity:	Smad1 (P457) pAb detects endogenous levels of Smad1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 424-478 of Human Smad1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Tissue Specificity:	Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Sequence Similarities:	Belongs to the dwarfin/SMAD family.
Post-Translational Modification:	Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271).
Database Links:	Entrez Gene: 4086?Human Entrez Gene: 17125?Mouse Entrez Gene: 25671?Rat Omim: 601595?Human SwissProt: Q15797?Human SwissProt: P70340?Mouse SwissProt: P97588?Rat Unigene: 604588?Human Unigene: 223717?Mouse Unigene: 10635?Rat
Synonyms:	BSP-1 Antibody BSP1 Antibody HsMAD1 Antibody JV4-1 Antibody JV41 Antibody MAD homolog 1 Antibody MAD mothers against decapentaplegic homolog 1 Antibody Mad related protein 1 Antibody Mad-related protein 1 Antibody MADH1 Antibody MADR1 Antibody Mothers against decapentaplegic homolog 1 Antibody Mothers against DPP homolog 1 Antibody SMA- AND MAD-RELATED PROTEIN 1 Antibody SMAD 1 Antibody SMAD family member 1 Antibody SMAD mothers against DPP homolog 1 Antibody Smad1 Antibody SMAD1_HUMAN Antibody TGF beta signaling protein 1 Antibody Transforming growth factor-beta-signaling protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.