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Anti-SIRT7 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SIRT7 Antibody

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Overview

Name:	Anti-SIRT7 Antibody See all SIRT7 primary antibodies
Description:	Rabbit polyclonal antibody to SIRT7
Specificity:	SIRT7 pAb detects endogenous levels of SIRT7 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human SIRT7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 44 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Sequence Similarities:	Belongs to the sirtuin family. Class IV subfamily.
Post-Translational Modification:	Phosphorylated during mitosis.
Cellular Location:	Cytoplasm. Nucleus > Nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Database Links:	Entrez Gene: 51547?Human Entrez Gene: 209011?Mouse Entrez Gene: 303745?Rat Omim: 606212?Human SwissProt: Q9NRC8?Human SwissProt: Q8BKJ9?Mouse SwissProt: B2RZ55?Rat Unigene: 514636?Human Unigene: 292957?Mouse Unigene: 23064?Rat
Synonyms:	NAD dependent deacetylase sirtuin 7 Antibody NAD dependent protein deacetylase sirtuin 7 Antibody NAD-dependent protein deacetylase sirtuin-7 Antibody Regulatory protein SIR2 homolog 7 Antibody Silent mating type information regulation 2 homolog Antibody Silent mating type information regulation 2 S.cerevisiae homolog 7 Antibody SIR2 L7 Antibody SIR2 like protein 7 Antibody Sir2 related protein type 7 Antibody SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 Antibody SIR2-like protein 7 Antibody SIR2L 7 Antibody SIR2L7 Antibody SIR7_HUMAN Antibody SIRT 7 Antibody SIRT7 Antibody Sirtuin 7 Antibody Sirtuin type 7 Antibody Sirtuin7 Antibody
Information:	Target information shown above is from the UniProt Consortium.