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Anti-SERPINA1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SERPINA1 Antibody

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Overview

Name:	Anti-SERPINA1 Antibody See all SERPINA1 primary antibodies
Description:	Rabbit polyclonal antibody to SERPINA1.
Applications:	WB
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human SERPINA1.
Protein Length:	418
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Tissue Specificity:	Ubiquitous. Expressed in leukocytes and plasma.
Involvement in Disease:	Alpha-1-antitrypsin deficiency: A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and *****s, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.
Sequence Similarities:	Belongs to the serpin family.
Post-Translational Modification:	N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant.
Cellular Location:	Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Database Links:	Entrez Gene: 5265?Human Omim: 107400?Human SwissProt: P01009?Human Unigene: 525557?Human
Synonyms:	A1A Antibody A1AT Antibody A1AT_HUMAN Antibody AAT Antibody Alpha 1 antiproteinase Antibody alpha 1 Antitrypsin Antibody Alpha 1 antitrypsin null Antibody Alpha 1 protease inhibitor Antibody Alpha-1 protease inhibitor Antibody Alpha-1-antiproteinase Antibody alpha1 proteinase inhibitor Antibody Alpha1AT Antibody Dom1 Antibody PI Antibody PI1 Antibody PRO2275 Antibody Serine (or cysteine) proteinase inhibitor clade A member 1 Antibody Serine protease inhibitor 1-1 Antibody Serine protease inhibitor A1a Antibody Serpin A1 Antibody Serpin A1a Antibody Serpin peptidase inhibitor clade A member 1 Antibody Serpina1 Antibody Short peptide from AAT Antibody SPAAT Antibody Spi1-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.