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Anti-Septin 6 Antibody

品牌：Antibodies

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规格：50µl

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Anti-Septin 6 Antibody

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Overview

Name:	Anti-Septin 6 Antibody See all Septin 6 primary antibodies
Description:	Rabbit polyclonal antibody to Septin 6
Specificity:	Septin 6 pAb detects endogenous levels of Septin 6 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 267-312 of Human Septin 6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 50 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular Location:	Cytoplasm. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere > Kinetochore. Cleavage furrow. Midbody. Cell projection > Cilium > Flagellum. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830).
Database Links:	Entrez Gene: 23157?Human Entrez Gene: 56526?Mouse Entrez Gene: 691335?Rat Omim: 300683?Human SwissProt: Q14141?Human SwissProt: Q9R1T4?Mouse Unigene: 496666?Human Unigene: 260036?Mouse Unigene: 48945?Rat
Synonyms:	KIAA0128 Antibody Nkrf Antibody RCG53214, isoform CRA_d Antibody RP5-876A24.2 Antibody SEP2 Antibody SEPT2 Antibody SEPT6 Antibody SEPT6/MLL FUSION GENE Antibody SEPT6_HUMAN Antibody Septin 2 Antibody Septin 6 Antibody Septin-6 Antibody
Information:	Target information shown above is from the UniProt Consortium.