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Anti-SEPT6 Antibody

品牌：Antibodies

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规格：100µg

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Anti-SEPT6 Antibody

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Name:	Anti-SEPT6 Antibody See all SEPT6 primary antibodies
Description:	Goat polyclonal antibody to SEPT6.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human Sep-06 (internal region).
Sequence:	C-DEVNAFKQRKTA
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular Location:	Cytoplasm. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere > Kinetochore. Cleavage furrow. Midbody. Cell projection > Cilium > Flagellum. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830).
Database Links:	Entrez Gene: 23157?Human Omim: 300683?Human SwissProt: Q14141?Human Unigene: 496666?Human
Synonyms:	KIAA0128 Antibody Nkrf Antibody RCG53214, isoform CRA_d Antibody RP5-876A24.2 Antibody SEP2 Antibody SEPT2 Antibody SEPT6 Antibody SEPT6/MLL FUSION GENE Antibody SEPT6_HUMAN Antibody Septin 2 Antibody Septin 6 Antibody Septin-6 Antibody
Information:	Target information shown above is from the UniProt Consortium.