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Anti-SENP1 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-SENP1 Antibody

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Name:	Anti-SENP1 Antibody See all SENP1 primary antibodies
Description:	Rabbit polyclonal antibody to SENP1
Specificity:	The antibody detects endogenous levels of total SENP1 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthesized peptide derived from N-terminal of human SENP1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Function:	Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Tissue Specificity:	Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Sequence Similarities:	Belongs to the peptidase C48 family.
Cellular Location:	Nucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.
Database Links:	Entrez Gene: 29843?Human Omim: 612157?Human SwissProt: Q9P0U3?Human Unigene: 603289?Human
Synonyms:	SENP 1 Antibody SENP1 Antibody SENP1_HUMAN Antibody Sentrin specific protease 1 Antibody Sentrin-specific protease 1 Antibody Sentrin/SUMO specific protease Antibody Sentrin/SUMO specific protease 1 Antibody Sentrin/SUMO specific protease SENP 1 Antibody Sentrin/SUMO specific protease SENP1 Antibody Sentrin/SUMO-specific protease SENP1 Antibody SUMO1/sentrin specific peptidase 1 Antibody SUMO1/sentrin specific protease 1 Antibody SuPr 2 Antibody SuPr2 Antibody
Information:	Target information shown above is from the UniProt Consortium.