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Anti-SBDS Antibody

品牌：Antibodies

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规格：50µl

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Anti-SBDS Antibody

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Overview

Name:	Anti-SBDS Antibody See all SBDS primary antibodies
Description:	Rabbit polyclonal antibody to SBDS.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SBDS.
Protein Length:	250
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
Tissue Specificity:	Widely expressed.
Involvement in Disease:	Shwachman-Diamond syndrome: Autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
Sequence Similarities:	Belongs to the SDO1/SBDS family.
Cellular Location:	Cytoplasm. Nucleus > Nucleolus. Nucleus > Nucleoplasm. Cytoplasm > Cytoskeleton > Spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).
Database Links:	Entrez Gene: 51119?Human Entrez Gene: 66711?Mouse Entrez Gene: 288615?Rat Omim: 607444?Human SwissProt: Q9Y3A5?Human SwissProt: P70122?Mouse SwissProt: Q5RK30?Rat Unigene: 110445?Human Unigene: 280484?Mouse Unigene: 107123?Rat
Synonyms:	4733401P19Rik Antibody AI836084 Antibody CGI 97 Antibody CGI-97 Antibody FLJ10917 Antibody MGC105922 Antibody Protein 22A3 Antibody Ribosome maturation protein SBDS Antibody sbds Antibody SBDS_HUMAN Antibody SDS Antibody Shwachman Bodian Diamond syndrome protein Antibody Shwachman Bodian Diamond syndrome protein homolog Antibody Shwachman Bodian-Diamond syndrome Antibody Shwachman-Bodian-Diamond syndrome protein Antibody SWDS Antibody
Information:	Target information shown above is from the UniProt Consortium.