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Anti-SATB1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SATB1 Antibody

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Overview

Name:	Anti-SATB1 Antibody See all SATB1 primary antibodies
Description:	Rabbit polyclonal antibody to SATB1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SATB1.
Protein Length:	763
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-s provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
Tissue Specificity:	Expressed predominantly in thymus.
Sequence Similarities:	Belongs to the CUT homeobox family.
Post-Translational Modification:	Sumoylated. Sumoylation promotes cleavage by caspases.
Cellular Location:	Nucleus matrix. Nucleus > PML body. Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
Database Links:	Entrez Gene: 6304?Human Entrez Gene: 20230?Mouse Entrez Gene: 316164?Rat Omim: 602075?Human SwissProt: Q01826?Human SwissProt: Q60611?Mouse Unigene: 517717?Human Unigene: 311655?Mouse Unigene: 233782?Rat
Synonyms:	DNA binding protein SATB1 Antibody DNA-binding protein SATB1 Antibody SATB homeobox 1 Antibody SATB1 Antibody SATB1_HUMAN Antibody Special AT rich sequence binding protein 1 Antibody Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA) Antibody Special AT-rich sequence-binding protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.