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Anti-SAMHD1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SAMHD1 Antibody

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Overview

Name:	Anti-SAMHD1 Antibody See all SAMHD1 primary antibodies
Description:	Rabbit polyclonal antibody to SAMHD1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SAMHD1.
Protein Length:	626
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Tissue Specificity:	Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.
Involvement in Disease:	Aicardi-Goutieres syndrome 5: A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Chilblain lupus 2: A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade.
Sequence Similarities:	Belongs to the SAMHD1 family.
Post-Translational Modification:	Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 25939?Human Omim: 606754?Human SwissProt: Q9Y3Z3?Human Unigene: 580681?Human
Synonyms:	CHBL2 Antibody DCIP Antibody Dendritic cell derived IFNG induced protein Antibody Dendritic cell-derived IFNG-induced protein Antibody Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Antibody dNTPase Antibody HD domain containing 1 Antibody HDDC1 Antibody Mg11 Antibody Monocyte protein 5 Antibody MOP 5 Antibody MOP-5 Antibody MOP5 Antibody OTTHUMP00000030889 Antibody SAM domain and HD domain 1 Antibody SAM domain and HD domain containing protein 1 Antibody SAM domain and HD domain-containing protein 1 Antibody SAMH1_HUMAN Antibody SAMHD1 Antibody SBBI88 Antibody
Information:	Target information shown above is from the UniProt Consortium.