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Anti-RUNX1 (T270) Antibody

品牌：Antibodies

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规格：50µl

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Anti-RUNX1 (T270) Antibody

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Overview

Name:	Anti-RUNX1 (T270) Antibody See all RUNX1 primary antibodies
Description:	Rabbit polyclonal antibody to RUNX1 (T270)
Specificity:	RUNX1 (T270) pAb detects endogenous levels of RUNX1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 250-300 of Human RUNX1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 55 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
Tissue Specificity:	Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Involvement in Disease:	Familial platelet disorder with associated myeloid malignancy: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Post-Translational Modification:	Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 861?Human Entrez Gene: 12394?Mouse Entrez Gene: 50662?Rat Omim: 151385?Human SwissProt: Q01196?Human SwissProt: Q03347?Mouse SwissProt: Q63046?Rat Unigene: 149261?Human Unigene: 612648?Human Unigene: 4081?Mouse Unigene: 470227?Mouse Unigene: 11201?Rat
Synonyms:	Acute myeloid leukemia 1 Antibody Acute myeloid leukemia 1 protein Antibody alpha subunit core binding factor Antibody AML 1 Antibody AML1 Antibody AML1 EVI 1 Antibody AML1 EVI 1 fusion protein Antibody Aml1 oncogene Antibody AMLCR 1 Antibody AMLCR1 Antibody CBF alpha 2 Antibody CBF-alpha-2 Antibody CBFA 2 Antibody CBFA2 Antibody Core binding factor alpha 2 subunit Antibody Core binding factor runt domain alpha subunit 2 Antibody Core-binding factor subunit alpha-2 Antibody EVI 1 Antibody EVI1 Antibody HGNC Antibody Oncogene AML 1 Antibody Oncogene AML-1 Antibody OTTHUMP00000108696 Antibody OTTHUMP00000108697 Antibody OTTHUMP00000108699 Antibody OTTHUMP00000108700 Antibody OTTHUMP00000108702 Antibody PEA2 alpha B Antibody PEA2-alpha B Antibody PEBP2 alpha B Antibody PEBP2-alpha B Antibody PEBP2A2 Antibody PEBP2aB Antibody Polyomavirus enhancer binding protein 2 alpha B subunit Antibody Polyomavirus enhancer-binding protein 2 alpha B subunit Antibody Run1 Antibody Runt related transcription factor 1 Antibody Runt-related transcription factor 1 Antibody RUNX 1 Antibody Runx1 Antibody RUNX1 / AML1 Antibody RUNX1_HUMAN Antibody SL3 3 enhancer factor 1 alpha B subunit Antibody SL3-3 enhancer factor 1 alpha B subunit Antibody SL3/AKV core binding factor alpha B subunit Antibody SL3/AKV core-binding factor alpha B subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.