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Anti-RPL13A Antibody

品牌：Antibodies

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规格：100µl

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Anti-RPL13A Antibody

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Overview

Name:	Anti-RPL13A Antibody See all RPL13A primary antibodies
Description:	Rabbit polyclonal antibody to RPL13A
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 197 of Human RPL13A
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3- and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Sequence Similarities:	Belongs to the universal ribosomal protein uL13 family.
Post-Translational Modification:	Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 23521?Human SwissProt: P40429?Human
Synonyms:	23 kD highly basic protein Antibody 23 kDa highly basic protein Antibody 60S ribosomal protein L13a Antibody L13A Antibody P198 Antibody Ribosomal protein L13a Antibody RPL 13A Antibody RPL13A Antibody Tissue specific transplantation antigen 1 Antibody Transplantation antigen P198 Antibody TSTA1 Antibody Tstap198 7 Antibody Tum antigen Antibody Tum P198 antigen Antibody
Information:	Target information shown above is from the UniProt Consortium.