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Anti-WTAP Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-WTAP Antibody

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Overview

Name:	Anti-WTAP Antibody See all WTAP primary antibodies
Description:	Rabbit polyclonal antibody to WTAP
Specificity:	The antibody detects endogenous levels of total WTAPv protein.
Applications:	WB
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from C-terminal of human WTAP.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Tissue Specificity:	Ubiquitously expressed.
Sequence Similarities:	Belongs to the fl(2)d family.
Cellular Location:	Nucleus > Nucleoplasm. Nucleus speckle.
Database Links:	Entrez Gene: 9589 Human Entrez Gene: 60532 Mouse Omim: 605442 Human SwissProt: Q15007 Human SwissProt: Q9ER69 Mouse Unigene: 446091 Human Unigene: 275521 Mouse
Synonyms:	DKFZp686F20131 Antibody Female-lethal(2)D homolog Antibody FL2D_HUMAN Antibody hFL(2)D Antibody KIAA0105 Antibody MGC3925 Antibody Mum2 Antibody OTTHUMP00000017522 Antibody OTTHUMP00000017523 Antibody PNAS 132 Antibody PNAS-132 Antibody PNAS132 Antibody Pre mRNA splicing regulator WTAP Antibody Pre-mRNA-splicing regulator WTAP Antibody Putative pre mRNA splicing regulator female lethal 2D homolog Antibody Putative pre mRNA splicing regulator female lethal(2D) Antibody Putative pre-mRNA splicing regulator female lethal(2D) homolog Antibody putative pre-mRNA splicing regulator female-lethal(2D) Antibody Wilms tumor 1 associated protein Antibody Wilms tumor 1 associating protein Antibody Wilms tumor 1-associating protein Antibody Wilms' tumor 1 associating protein Antibody Wilms' tumour 1-associating protein Antibody WT1 associated protein Antibody WT1-associated protein Antibody WT1-associating protein Antibody WTAP Antibody
Information:	Target information shown above is from the UniProt Consortium.