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Anti-WNT7A Antibody

品牌：Antibodies

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规格：50µl

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Anti-WNT7A Antibody

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Overview

Name:	Anti-WNT7A Antibody See all WNT7A primary antibodies
Description:	Rabbit polyclonal antibody to WNT7A.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WNT7A.
Protein Length:	349
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).
Tissue Specificity:	Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and ***** brain.
Involvement in Disease:	Limb pelvis hypoplasia aplasia syndrome: A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Fuhrmann syndrome: Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 7476?Human Entrez Gene: 22421?Mouse Entrez Gene: 114850?Rat Omim: 601570?Human SwissProt: O00755?Human SwissProt: P24383?Mouse Unigene: 72290?Human Unigene: 56964?Mouse Unigene: 230035?Rat
Synonyms:	Protein Wnt-7a Antibody Protein Wnt-7a precursor Antibody Proto oncogene Wnt7a protein Antibody proto-oncogene wnt7a protein Antibody wingless-type MMTV integration site family, member 7A Antibody Wnt family member 7A Antibody Wnt7a Antibody WNT7A_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.