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Anti-WNT4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-WNT4 Antibody

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Overview

Name:	Anti-WNT4 Antibody See all WNT4 primary antibodies
Description:	Mouse monoclonal antibody to WNT4.
Applications:	WB, IHC, IF, IP
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:50 - 1:100, IP: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide of human WNT4.
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
Involvement in Disease:	46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs: A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. Mullerian aplasia and hyperandrogenism: A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 54361?Human Entrez Gene: 22417?Mouse Entrez Gene: 84426?Rat Omim: 603490?Human SwissProt: P56705?Human SwissProt: P22724?Mouse SwissProt: Q9QXQ5?Rat Unigene: 25766?Human Unigene: 611722?Human Unigene: 20355?Mouse Unigene: 34782?Rat
Synonyms:	MGC123964 Antibody Protein Wnt-4 Antibody RP23-246F18.1 Antibody SERKAL Antibody Wingless type MMTV integration site family member 4 precursor Antibody WNT 4 Antibody WNT 4 protein precursor Antibody Wnt4 Antibody WNT4_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.