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Anti-WNT3A Antibody

品牌：Antibodies

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规格：100µl

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Anti-WNT3A Antibody

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Name:	Anti-WNT3A Antibody See all WNT3A primary antibodies
Description:	Rabbit polyclonal antibody to WNT3A
Specificity:	The antibody detects endogenous level of total WNT3A antibody.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WNT3A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Function:	Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Tissue Specificity:	Moderately expressed in placenta and at low levels in ***** lung, spleen, and prostate.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Palmitoleylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleylated WNT3A from WLS in secretory vesicles (PubMed:20826466, PubMed:21244856, PubMed:24292069). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway, possibly by promoting disulfide bond formation and oligomerization (PubMed:25731175).
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 89780 Human Entrez Gene: 22416 Mouse Omim: 606359 Human SwissProt: P56704 Human SwissProt: P27467 Mouse Unigene: 336930 Human Unigene: 1367 Mouse
Synonyms:	Protein Wnt 3a Precursor Antibody Protein Wnt-3a Antibody Wingless type MMTV integration site family member 3A Antibody Wnt 3a Antibody Wnt3a Antibody WNT3A protein Antibody WNT3A_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.