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Anti-WNT10B Antibody

品牌：Antibodies

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规格：100µl

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Anti-WNT10B Antibody

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Overview

Name:	Anti-WNT10B Antibody See all WNT10B primary antibodies
Description:	Rabbit polyclonal antibody to WNT10B
Specificity:	The antibody detects endogenous levels of total WNT10B protein.
Applications:	WB
Reactivity:	Human
Immunogen:	Synthetic peptide of human WNT10B
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3.15mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20˚C

Target

Function:	Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
Tissue Specificity:	Detected in most ***** tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
Involvement in Disease:	Split-hand/foot malformation 6: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Tooth agenesis, selective, 8: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 7480 Human Omim: 601906 Human SwissProt: O00744 Human Unigene: 91985 Human
Synonyms:	Protein Wnt-10b Antibody Protein Wnt-12 Antibody SHFM6 Antibody wingless type MMTV integration site family, member 10B Antibody WN10B_HUMAN Antibody WNT 10B protein Antibody WNT 12 Antibody Wnt10b Antibody wnt12 Antibody
Information:	Target information shown above is from the UniProt Consortium.