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Anti-WNK2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-WNK2 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-WNK2 Antibody See all WNK2 primary antibodies
Description:	Rabbit polyclonal antibody to WNK2
Specificity:	WNK2 pAb detects endogenous levels of WNK2 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human WNK2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 243 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Target

Function:	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Tissue Specificity:	Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Post-Translational Modification:	Autophosphorylated.
Cellular Location:	Cytoplasm. Cell membrane.
Database Links:	Entrez Gene: 65268 Human Entrez Gene: 75607 Mouse Entrez Gene: 306811 Rat Omim: 606249 Human SwissProt: Q9Y3S1 Human SwissProt: Q3UH66 Mouse Unigene: 522291 Human Unigene: 342723 Mouse Unigene: 30163 Rat
Synonyms:	Antigen NY-CO-43 Antibody KIAA1760 Antibody mitogen-activated protein kinase kinase kinase Antibody NY CO 43 Antibody P/OKcl.13 Antibody PRKWNK2 Antibody Protein kinase lysine deficient 2 Antibody Protein kinase with no lysine 2 Antibody SDCCAG43 Antibody Serine/Threonine protein kinase WNK2 Antibody Serologically defined colon cancer antigen 43 Antibody WNK lysine deficient protein kinase 2 Antibody WNK2 Antibody
Information:	Target information shown above is from the UniProt Consortium.