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Anti-WIPI1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-WIPI1 Antibody

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Overview

Name:	Anti-WIPI1 Antibody See all WIPI1 primary antibodies
Description:	Rabbit polyclonal antibody to WIPI1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WIPI1.
Protein Length:	446
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
Tissue Specificity:	Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.
Sequence Similarities:	Belongs to the WD repeat SVP1 family.
Cellular Location:	Golgi apparatus > trans-Golgi network. Endosome. Cytoplasmic vesicle > Clathrin-coated vesicle. Preautophagosomal structure membrane. Cytoplasm > Cytoskeleton. Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
Database Links:	Entrez Gene: 55062?Human Entrez Gene: 52639?Mouse Entrez Gene: 303630?Rat Omim: 609224?Human SwissProt: Q5MNZ9?Human SwissProt: Q8R3E3?Mouse Unigene: 463964?Human Unigene: 35817?Mouse
Synonyms:	ATG 18 Antibody ATG18 Antibody Atg18 protein homolog Antibody ATG18A Antibody FLJ10055 Antibody WD repeat domain phosphoinositide interacting 1 Antibody WD repeat domain phosphoinositide interacting protein 1 Antibody WD repeat domain phosphoinositide-interacting protein 1 Antibody WD40 repeat protein interacting with phosphoinositides of 49 kDa Antibody WD40 repeat protein interacting with phosphoInositides of 49kDa Antibody WIPI 1 Antibody WIPI 1 alpha Antibody WIPI 49 Antibody WIPI 49 kDa Antibody WIPI-1 Antibody WIPI1 Antibody WIPI1_HUMAN Antibody WIPI49 Antibody
Information:	Target information shown above is from the UniProt Consortium.