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Anti-WEE1 (Phospho-Ser642) Antibody

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规格：50µl

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Anti-WEE1 (Phospho-Ser642) Antibody

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Overview

Name:	Anti-WEE1 (Phospho-Ser642) Antibody See all WEE1 primary antibodies
Description:	Rabbit polyclonal antibody to WEE1 (Phospho-Ser642)
Specificity:	The antibody detects endogenous levels of WEE1 only when phosphorylated at serine 642.
Applications:	WB
Dilutions:	Western blotting: 1:500~1:1000
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of Serine 642(S-V-S(p)-L-T) derived from Human WEE1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C / 1 year

Target

Function:	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Post-Translational Modification:	Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 7465 Human Entrez Gene: 22390 Mouse Entrez Gene: 308937 Rat Omim: 193525 Human SwissProt: P30291 Human SwissProt: P47810 Mouse SwissProt: Q63802 Rat Unigene: 249441 Human Unigene: 287173 Mouse Unigene: 208255 Rat
Synonyms:	DKFZp686I18166 Antibody EC 2.7.10.2 Antibody FLJ16446 Antibody MGC105683 Antibody OTTHUMP00000231338 Antibody OTTHUMP00000231339 Antibody Wee 1 Antibody WEE 1 homolog 1 (S. pombe) Antibody Wee1 Antibody Wee1 homolog Antibody WEE1 homolog (S. pombe) Antibody WEE1 homolog S. pombe Antibody Wee1 like protein kinase Antibody Wee1 tyrosine kinase Antibody Wee1+ homolog Antibody Wee1+ S. pombe homolog Antibody WEE1, S. pombe, homolog of Antibody WEE1, somatic Antibody Wee1-like protein kinase Antibody WEE1A Antibody Wee1A kinase Antibody WEE1hu Antibody WEE1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.