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Anti-WDR77 Antibody

品牌：Antibodies

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规格：50µl

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Anti-WDR77 Antibody

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Overview

Name:	Anti-WDR77 Antibody See all WDR77 primary antibodies
Description:	Mouse monoclonal antibody to WDR77.
Applications:	WB, ICC
Dilutions:	WB: 1:500 - 1:2000, ICC: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human WDR77.
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Tissue Specificity:	Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.
Cellular Location:	Nucleus. Cytoplasm. Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In ***** testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
Database Links:	Entrez Gene: 79084 Human Omim: 611734 Human SwissProt: Q9BQA1 Human Unigene: 204773 Human
Synonyms:	2610312E17Rik Antibody Androgen receptor cofactor p44 Antibody C79984 Antibody HKMT1069 Antibody MEP 50 Antibody MEP-50 Antibody MEP50 Antibody MEP50_HUMAN Antibody Methylosome protein 50 Antibody MGC2722 Antibody Nbla10071 Antibody p44 Antibody p44/Mep50 Antibody RGD1310479 Antibody RP11 552M11.3 Antibody WD repeat containing protein 77 Antibody WD repeat domain 77 Antibody WD repeat-containing protein 77 Antibody WDR77 Antibody
Information:	Target information shown above is from the UniProt Consortium.