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Anti-WDR41 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-WDR41 Antibody

商品详情参考文献相关资料

Name:	Anti-WDR41 Antibody See all WDR41 primary antibodies
Description:	Rabbit polyclonal antibody to WDR41
Specificity:	The antibody detects endogenous levels of total WDR41 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Fusion protein of human WDR41
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	0.7mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Function:	Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 55255?Human SwissProt: Q9HAD4?Human Unigene: 482573?Human
Synonyms:	FLJ10904 Antibody MSTP048 Antibody WD repeat domain 41 Antibody WD repeat protein 41 Antibody WD repeat-containing protein 41 Antibody WDR 41 Antibody WDR41 Antibody WDR41_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.