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Anti-WASP Antibody

品牌：Antibodies

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规格：50µl

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Anti-WASP Antibody

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Overview

Name:	Anti-WASP Antibody See all WASP primary antibodies
Description:	Rabbit polyclonal antibody to WASP
Specificity:	The antibody detects endogenous level of total WASP protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around aa.289~293 (L-I-Y-D-F) derived from Human WASP.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.
Tissue Specificity:	Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
Involvement in Disease:	Wiskott-Aldrich syndrome: An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10. Thrombocytopenia 1: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. Neutropenia, severe congenital, X-linked: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
Post-Translational Modification:	Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.
Cellular Location:	Cytoplasm > Cytoskeleton.
Database Links:	Entrez Gene: 7454 Human Entrez Gene: 22376 Mouse Entrez Gene: 317371 Rat Omim: 300392 Human SwissProt: P42768 Human SwissProt: P70315 Mouse Unigene: 2157 Human Unigene: 4735 Mouse
Synonyms:	Eczema thrombocytopenia Antibody IMD2 Antibody SCNX Antibody THC Antibody THC1 Antibody Thrombocytopenia 1 (X linked) Antibody U42471 Antibody Was Antibody WASP Antibody WASP_HUMAN Antibody Wiskott Aldrich syndrome Antibody Wiskott Aldrich syndrome (eczema thrombocytopenia) Antibody Wiskott Aldrich syndrome protein Antibody Wiskott-Aldrich syndrome protein Antibody
Information:	Target information shown above is from the UniProt Consortium.