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Anti-VRK2 Antibody

品牌：Antibodies

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规格：100µg

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Anti-VRK2 Antibody

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Overview

Name:	Anti-VRK2 Antibody See all VRK2 primary antibodies
Description:	Goat polyclonal antibody to VRK2.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human VRK2 (internal region).
Sequence:	C-PNSQKVDSQKAATK
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Tissue Specificity:	Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.
Sequence Similarities:	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Post-Translational Modification:	Isoform 1 and isoform 2 are autophosphorylated.
Cellular Location:	Cytoplasm. Endoplasmic reticulum membrane. Mitochondrion membrane.
Database Links:	Entrez Gene: 7444 Human Omim: 602169 Human SwissProt: Q86Y07 Human Unigene: 728198 Human
Synonyms:	2810003O05Rik Antibody AI447698 Antibody EC 2.7.11.1 Antibody Serine/threonine protein kinase VRK2 Antibody Serine/threonine-protein kinase VRK2 Antibody Vaccinia related kinase 2 Antibody Vaccinia virus B1R related kinase 2 Antibody Vaccinia-related kinase 2 Antibody VRK 2 Antibody VRK2 Antibody VRK2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.