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Anti-Heme oxygenase 1 protein Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-Heme oxygenase 1 protein Antibody

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Name:	Anti-Heme oxygenase 1 protein Antibody See all Heme oxygenase 1 protein primary antibodies
Description:	Rabbit polyclonal antibody to Heme oxygenase 1 protein
Specificity:	The antibody detects endogenous level of total Heme oxygenase 1 protein polyclonal antibody.
Applications:	IHC
Reactivity:	Human
Immunogen:	Recombinant human Heme oxygenase 1 protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20?C

Function:	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Tissue Specificity:	Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Involvement in Disease:	Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Sequence Similarities:	Belongs to the heme oxygenase family.
Cellular Location:	Microsome. Endoplasmic reticulum membrane.